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Image Search Results
Journal: Stem cells (Dayton, Ohio)
Article Title: Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain.
doi: 10.1634/stemcells.2007-0543
Figure Lengend Snippet: Figure 6. Binding and migration of human MSCs in vitro. (A): Binding of human MSCs to culture dishes coated with 10 g/ml of FN, CDH2, or NTRN1. The number of cells bound to FN-coated plates was significantly greater at all cell doses as compared with CDH2 or NTRN1-coated plates (p .0006). Preincubation of CDH2-coated plates with soluble CDH2 protein or (B) preincubation of MSCs with a neutralizing anti-NEO1 antibody (C) inhibited cell binding to CHD2 or NTRN1, respectively, in a dose-dependent fashion; , p 1 108. (D): Migration of human MSCs in response to SDF-1 and RGMA (25 g/ml) or VEGF165 and VEGF121 (10 g/ml) was significantly greater compared with medium alone; , p 5 109. Cell migration in response to RGMA was abolished by pretreatment of cells with a neutralizing anti-NEO1 antibody. (E): Migration of MSCs in response to VEGF165 was partially inhibited by preincubation of cells with anti-FLK1 and/or anti-FLT1 antibodies; , p .001; , p 1 109. (F): Migration of MSCs in response to VEGF121 was completely abolished by preincubating cells with anti-FLK1 and/or anti-FLT1 antibodies; , p 1 1011; , p 5 105. Abbreviations: CDH, cadherin; FN, fibronectin; NEO, neogenin; NTRN, netrin; OD, optical density; RGMA, repulsive guidance molecule A; SDF, stromal cell-derived factor; VEGF, vascular endothelial growth factor.
Article Snippet: Wells were precoated with 2–50 g/ml (200 l) recombinant mouse netrin 1, recombinant human cadherin 2, or
Techniques: Binding Assay, Migration, In Vitro, Derivative Assay
Journal: Biochemical pharmacology
Article Title: POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITION COUNTERACTS MULTIPLE MANIFESTATIONS OF KIDNEY DISEASE IN LONG-TERM STREPTOZOTOCIN-DIABETIC RAT MODEL
doi: 10.1016/j.bcp.2009.11.018
Figure Lengend Snippet: PARP inhibition essentially prevents diabetes-induced renal cortex fibronectin accumulation. C – control group; D – diabetic group. Mean ± SEM; n = 7–10 per group. ** - p <0.01 vs controls; ## - p < 0.01 vs untreated diabetic group.
Article Snippet: Supernatant fibronectin concentrations were measured with the
Techniques: Inhibition